Question

In which of these conditions may CPK be raised?

• A. Muscle disease
• B. Liver cirrhosis
• C. Biliary colic
• D. Amyotrophic lateral sclerosis

Hint:

CPK sits inside muscle cells; think about which option actually damages muscle fibers.

Answer 1

The Correct Option is A

Step 1: Understanding the Question:
CPK, or creatine phosphokinase, is an enzyme found mainly inside muscle cells. The question asks which of the four listed conditions raises its blood level.

Step 2: Key Concept:
CPK sits inside skeletal muscle, heart muscle, and brain tissue. When any of these cells break down or get damaged, the enzyme leaks out into the blood and the serum CPK level goes up. So the level rises with muscle injury, not with problems in organs that do not hold much CPK.

Step 3: Detailed Explanation:
Muscle disease, such as myositis, muscular dystrophy, or a heart attack, damages muscle fibers directly, so CPK pours into the blood and the level rises sharply.
Liver cirrhosis mainly raises liver enzymes like ALT, AST, and ALP, along with bilirubin. It does not damage muscle, so CPK stays normal.
Biliary colic points to a gallstone blocking the bile duct. This raises ALP, GGT, and bilirubin, again with no effect on muscle enzymes.
Amyotrophic lateral sclerosis mainly destroys the nerve cells that drive muscles (anterior horn cells), not the muscle fibers themselves. CPK in ALS is usually normal or only mildly raised, nowhere near the rise seen in true muscle disease.

Step 4: Final Answer:
Only direct muscle damage explains a clearly raised CPK, so the answer is muscle disease.