Concept:
For a triangle,
\[
c^2=a^2+b^2-2ab\cos C
\]
(Law of Cosines)
and
\[
c=2R\sin C
\]
(Extended Law of Sines).
Using these two formulas, we can find the circumradius \(R\).
Step 1: Find the side \(c\) using the Law of Cosines.
Given
\[
a=2,\qquad b=4,\qquad \cos C=-\frac{5}{16}.
\]
Therefore,
\[
c^2
=
a^2+b^2-2ab\cos C.
\]
\[
=
2^2+4^2-2(2)(4)\left(-\frac{5}{16}\right).
\]
\[
=
4+16+5.
\]
\[
=25.
\]
Hence,
\[
c=5.
\]
Step 2: Find \(\sin C\).
Using
\[
\sin^2C+\cos^2C=1,
\]
we get
\[
\sin C
=
\sqrt{1-\left(-\frac{5}{16}\right)^2}.
\]
\[
=
\sqrt{1-\frac{25}{256}}.
\]
\[
=
\sqrt{\frac{231}{256}}.
\]
\[
=
\frac{\sqrt{231}}{16}.
\]
Since \(C\) is an angle of a triangle,
\[
\sin C>0.
\]
Thus,
\[
\sin C=\frac{\sqrt{231}}{16}.
\]
Step 3: Use the Extended Law of Sines.
\[
c=2R\sin C.
\]
Substituting \(c=5\),
\[
5
=
2R\left(\frac{\sqrt{231}}{16}\right).
\]
\[
5
=
R\left(\frac{\sqrt{231}}{8}\right).
\]
Therefore,
\[
R
=
\frac{40}{\sqrt{231}}.
\]
Step 4: Write the final answer.
\[
\boxed{\frac{40}{\sqrt{231}}}
\]