In a homologous series of any general anesthetic, increasing the chain length increases the lipid solubility and produces a corresponding increase in anesthetic potency, is proposed by:
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- John Pemberton
- Meyer - Overton
- Hubert Humphrey
- Meyer - Philip
The Correct Option is B
Solution and Explanation
Step 1: Understanding the Meyer-Overton correlation. The Meyer-Overton hypothesis states that the potency of general anesthetics is directly proportional to their lipid solubility. This means that as the lipid solubility of a compound increases (e.g., with increasing chain length in a homologous series), its anesthetic potency also increases.
Step 2: Importance of lipid solubility in anesthetic action. Lipid solubility is critical for anesthetic agents because they must cross the lipid-rich membranes of nerve cells to exert their effect. The Meyer-Overton hypothesis highlights this relationship.
Step 3: Why other options are incorrect. - (A) John Pemberton: Associated with Coca-Cola's invention, not anesthetics.
- (C) Hubert Humphrey: A politician, unrelated to pharmacology or anesthetic theories.
- (D) Meyer - Philip: Does not correspond to any theory in anesthetics.
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