Question

Impaired function of Aquaporin results in

• A. Liddel syndrome
• B. Nephrogenic DI
• C. Cystic fibrosis
• D. Barter syndrome

Answer 1

The Correct Option is B

Aquaporins are integral membrane proteins that serve as channels in the transfer of water, and in some cases, small solutes across the cell membrane. When the function of Aquaporins is impaired, it can lead to a condition known as Nephrogenic Diabetes Insipidus (DI).

Nephrogenic DI occurs because the kidneys are unable to concentrate urine due to the lack of response to the antidiuretic hormone (ADH), also known as vasopressin. In this condition, even though ADH levels may be normal, the defective Aquaporins prevent adequate water reabsorption in the kidney's collecting ducts.

The other options, such as Liddle Syndrome, Cystic Fibrosis, and Barter Syndrome, are not directly related to the dysfunction of Aquaporins:

Condition	Description
Liddle Syndrome	A genetic disorder causing hypertension due to increased activity of sodium channels.
Nephrogenic DI	Impaired water reabsorption due to defective Aquaporins or their response.
Cystic Fibrosis	A genetic disorder affecting exocrine glands leading to thick mucus production.
Barter Syndrome	A disorder affecting kidney's ability to reabsorb salts properly.

Thus, the impaired function of Aquaporins is associated with Nephrogenic Diabetes Insipidus.