Question:
Hyperacute graft rejection occurs after how much time following transplantation?
Hyperacute graft rejection occurs after how much time following transplantation?
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Pre-formed antibodies act the instant blood perfuses the graft - think operating table.
Updated On: Jun 23, 2026
- 24 hours
- 2 weeks
- Within minutes
- Years
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The Correct Option is C
Solution and Explanation
Step 1: Graft rejection is classified by its timing into hyperacute, acute, and chronic forms. The question targets the fastest of these.
Step 2: Hyperacute rejection occurs almost immediately, within minutes of grafting, and is often evident on the operating table while the patient is still in surgery. This makes option (c) correct.
Step 3: The mechanism is pre-formed recipient antibodies against donor antigens, classically from ABO blood-group mismatch, which trigger immediate complement activation, thrombosis, and graft loss.
Step 4: Contrast with the distractors - acute rejection develops over days to a few weeks, and chronic rejection occurs over months to years. Hence the hyperacute form occurs within minutes.
Step 2: Hyperacute rejection occurs almost immediately, within minutes of grafting, and is often evident on the operating table while the patient is still in surgery. This makes option (c) correct.
Step 3: The mechanism is pre-formed recipient antibodies against donor antigens, classically from ABO blood-group mismatch, which trigger immediate complement activation, thrombosis, and graft loss.
Step 4: Contrast with the distractors - acute rejection develops over days to a few weeks, and chronic rejection occurs over months to years. Hence the hyperacute form occurs within minutes.
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