Question

Glycine can be obtained from formaldehyde by

• A. Strecker synthesis
• B. Williamson's synthesis
• C. Phthalimide synthesis
• D. Coupling reaction

Hint:

Williamson's synthesis is for ethers, Phthalimide synthesis for primary amines, and coupling reaction for azo compounds.

Answer 1

The Correct Option is A

Step 1: Understanding the Concept:
Strecker synthesis is a method for preparing amino acids from aldehydes.
Step 2: Detailed Explanation:
In Strecker synthesis, an aldehyde (formaldehyde, HCHO) is treated with ammonia (NH\(_3\)) and hydrogen cyanide (HCN) to form an \(\alpha\)-aminonitrile, which is then hydrolyzed to give the \(\alpha\)-amino acid (glycine). \[ HCHO + NH_3 + HCN \rightarrow H_2N-CH_2-CN \xrightarrow{H_2O/H^+} H_2N-CH_2-COOH \]
Step 3: Final Answer:
Glycine can be obtained from formaldehyde by Strecker synthesis, option (A).