Question:
Follicular lymphoma shows positivity for which of the following?
Follicular lymphoma shows positivity for which of the following?
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The t(14;18) translocation overexpresses this anti-apoptotic protein.
Updated On: Jun 23, 2026
- Bcl-1
- Bcl-6
- Bcl-2
- None of the above
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The Correct Option is C
Solution and Explanation
Step 1: Follicular lymphoma is a B-cell non-Hodgkin lymphoma defined by a characteristic chromosomal translocation.
Step 2: The t(14;18) translocation places the BCL-2 gene (normally on chromosome 18) next to the immunoglobulin heavy chain enhancer on chromosome 14, causing overexpression of the BCL-2 protein.
Step 3: Because BCL-2 normally blocks apoptosis, its overexpression makes the lymphoma cells resistant to programmed cell death, so they accumulate. Hence follicular lymphoma is BCL-2 positive, making option (c) correct.
Step 4: Bcl-1 (cyclin D1) marks mantle cell lymphoma and Bcl-6 is linked with diffuse large B-cell and normal germinal-centre cells, so options (a) and (b) are not the defining positivity here.
Step 2: The t(14;18) translocation places the BCL-2 gene (normally on chromosome 18) next to the immunoglobulin heavy chain enhancer on chromosome 14, causing overexpression of the BCL-2 protein.
Step 3: Because BCL-2 normally blocks apoptosis, its overexpression makes the lymphoma cells resistant to programmed cell death, so they accumulate. Hence follicular lymphoma is BCL-2 positive, making option (c) correct.
Step 4: Bcl-1 (cyclin D1) marks mantle cell lymphoma and Bcl-6 is linked with diffuse large B-cell and normal germinal-centre cells, so options (a) and (b) are not the defining positivity here.
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