Question:
Flexner-Wintersteiner rosette is seen in?
Flexner-Wintersteiner rosette is seen in?
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Cells around an empty lumen with cytoplasmic projections - retinal tumor.
Updated On: Jun 24, 2026
- Hepatoblastoma
- Nephroblastoma
- Neuroblastoma
- Retinoblastoma
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The Correct Option is D
Solution and Explanation
Step 1: Rosettes are spoke-wheel arrangements of tumor cells around a central core. The Flexner-Wintersteiner rosette is characteristic of retinoblastoma.
Step 2: In a Flexner-Wintersteiner rosette a halo of tumor cells surrounds a small, largely empty central lumen, into which slender cytoplasmic processes from the cells project. This reflects photoreceptor differentiation, fitting the retinal origin of retinoblastoma. It may also be found in medulloblastoma, PNET and pineoblastoma.
Step 3: Why the others are wrong - neuroblastoma classically shows Homer-Wright rosettes, in which cells surround a central tangle of neuropil fibrils. Nephroblastoma (Wilms tumor) shows a triphasic blastemal, epithelial and stromal pattern, and hepatoblastoma shows fetal and embryonal hepatocytes, neither giving Flexner-Wintersteiner rosettes.
Answer: Retinoblastoma.
Step 2: In a Flexner-Wintersteiner rosette a halo of tumor cells surrounds a small, largely empty central lumen, into which slender cytoplasmic processes from the cells project. This reflects photoreceptor differentiation, fitting the retinal origin of retinoblastoma. It may also be found in medulloblastoma, PNET and pineoblastoma.
Step 3: Why the others are wrong - neuroblastoma classically shows Homer-Wright rosettes, in which cells surround a central tangle of neuropil fibrils. Nephroblastoma (Wilms tumor) shows a triphasic blastemal, epithelial and stromal pattern, and hepatoblastoma shows fetal and embryonal hepatocytes, neither giving Flexner-Wintersteiner rosettes.
Answer: Retinoblastoma.
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