Question:
Examples of BCS class III drugs are:
Examples of BCS class III drugs are:
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BCS Class III drugs have good solubility but low permeability, making them ideal candidates for formulations that can enhance their absorption and bioavailability.
Updated On: Jul 14, 2026
- Acyclovir, Atenolol, Captopril
- Taxol, Ellagic acid, Aspirin
- Aspirin, Paracetamol, Amoxycillin
- Chloroquine, Diltiazem, Metoprolol
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The Correct Option is A
Approach Solution - 1
BCS Class III drugs are characterized by high solubility and low permeability. Drugs like Acyclovir, Atenolol, and Captopril fall under this class due to their high solubility but relatively low permeability across the gastrointestinal tract. These drugs often benefit from formulations that enhance their absorption.
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Approach Solution -2
The Biopharmaceutics Classification System sorts drugs by solubility and permeability. BCS Class III drugs are high solubility, low permeability. Let's check each group of drugs against this definition.
- Acyclovir, Atenolol, Captopril: All three of these drugs dissolve readily in water (high solubility) but cross the intestinal membrane poorly because they are relatively polar molecules that do not partition well into the lipid membrane (low permeability). This combination is exactly the BCS Class III profile, which is also why these drugs often show incomplete and variable oral absorption despite dissolving fully.
- Taxol, Ellagic acid, Aspirin: Taxol is a poorly water-soluble drug with good permeability, placing it in BCS Class II, not Class III. This group mixes drugs of different classes and does not fit the low permeability, high solubility profile as a set.
- Aspirin, Paracetamol, Amoxycillin: Aspirin and paracetamol are both reasonably soluble and readily cross membranes, making them BCS Class I drugs. This trio does not represent the low permeability profile that defines Class III.
- Chloroquine, Diltiazem, Metoprolol: These drugs are lipophilic and cross membranes easily, giving them high permeability, which places them closer to BCS Class I rather than Class III.
Only the first group, acyclovir, atenolol, and captopril, combines high aqueous solubility with poor membrane permeability, matching the BCS Class III definition.
Therefore, the correct answer is Acyclovir, Atenolol, Captopril.
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