Concept:
Use the substitution method when the integrand contains a function and its derivative.
Recall the derivative:
\[
\frac{d}{dx}(\cot^{-1}x) = -\frac{1}{1+x^2}
\]
For a composite function:
\[
\frac{d}{dx}(\cot^{-1}(x^3)) = -\frac{3x^2}{1+x^6}
\]
Step 1: {Choose substitution.}
Let
\[
t = \cot^{-1}(x^3)
\]
Then
\[
\frac{dt}{dx} = -\frac{3x^2}{1+x^6}
\]
\[
dt = -\frac{3x^2}{1+x^6}\,dx
\]
Step 2: {Rewrite the given integral.}
\[
\int \frac{4x^2 \cot^{-1}(x^3)}{1+x^6}dx
\]
Using substitution:
\[
\frac{4x^2}{1+x^6}dx = -\frac{4}{3}dt
\]
Thus the integral becomes
\[
\int t\left(-\frac{4}{3}\right)dt
\]
Step 3: {Integrate.}
\[
-\frac{4}{3}\int t\,dt
\]
\[
= -\frac{4}{3}\cdot \frac{t^2}{2}
\]
\[
= -\frac{2}{3}t^2
\]
Step 4: {Substitute back \(t\).}
\[
t = \cot^{-1}(x^3)
\]
Therefore,
\[
\int \frac{4x^2 \cot^{-1}(x^3)}{1+x^6}\,dx
=
-\frac{2}{3}(\cot^{-1}(x^3))^2 + C
\]
Hence, the correct option is (C).