Question:
During the expression of a gene in a eukaryotic organism, a series of events happen one after another. Arrange the following steps of gene expression in eukaryotes chronologically i.e. from the first to the last-
(A). Movement of the matured mRNA from the nucleus to the cytoplasm
(B). Formation of transcript (pre-mRNA) in the nucleus
(C). Removal of the introns, joining the exons, and addition of 5'cap and poly-A tail to the pre-mRNA
(D). Attachment of the mRNA with the Ribosome for translation in the cytoplasm
Choose the correct answer from the options given below:
During the expression of a gene in a eukaryotic organism, a series of events happen one after another. Arrange the following steps of gene expression in eukaryotes chronologically i.e. from the first to the last-
(A). Movement of the matured mRNA from the nucleus to the cytoplasm
(B). Formation of transcript (pre-mRNA) in the nucleus
(C). Removal of the introns, joining the exons, and addition of 5'cap and poly-A tail to the pre-mRNA
(D). Attachment of the mRNA with the Ribosome for translation in the cytoplasm
Choose the correct answer from the options given below:
(A). Movement of the matured mRNA from the nucleus to the cytoplasm
(B). Formation of transcript (pre-mRNA) in the nucleus
(C). Removal of the introns, joining the exons, and addition of 5'cap and poly-A tail to the pre-mRNA
(D). Attachment of the mRNA with the Ribosome for translation in the cytoplasm
Choose the correct answer from the options given below:
Show Hint
Remember:
Nucleus = Transcription (B) followed by Processing (C).
Cytoplasm = Nuclear export (A) followed by translation on ribosomes (D).
This spatial division defines the sequence of eukaryotic gene expression.
Nucleus = Transcription (B) followed by Processing (C).
Cytoplasm = Nuclear export (A) followed by translation on ribosomes (D).
This spatial division defines the sequence of eukaryotic gene expression.
Updated On: Aug 3, 2026
- (B), (C), (A), (D).
- (D), (B), (C), (A).
- (B), (A), (D), (C).
- (C), (B), (D), (A).
Show Solution
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The Correct Option is A
Solution and Explanation
Step 1: Understanding the Concept:
Gene expression in eukaryotes is spatially and temporally divided due to the compartmentalization of the cell.
Transcription and RNA processing occur within the nucleus, whereas translation of mature mRNA into a polypeptide chain occurs within the cytoplasm.
Step 2: Detailed Explanation:
Let us organize the steps of eukaryotic gene expression in chronological order:
1.
Step 1: Transcription (B): The enzyme RNA polymerase II transcribes the genomic DNA template in the nucleus to synthesize a primary RNA transcript, also known as pre-mRNA.
2. Co-transcriptional and Post-transcriptional Processing (C): The nascent pre-mRNA undergoes several modifications in the nucleus before it is functional:
- Addition of a 7-methylguanosine cap at the 5' end.
- Cleavage of the 3' end and addition of a polyadenylated (poly-A) tail.
- Splicing to remove non-coding introns and join coding exons, catalyzed by the spliceosome complex.
This generates a mature mRNA molecule.
3.
Step 2: Nucleocytoplasmic Export (A): The mature, fully processed mRNA is exported from the nucleus into the cytoplasm through the nuclear pore complexes.
4.
Step 3: Translation (D): In the cytoplasm, the mature mRNA binds to ribosomes, which translate the nucleotide sequence into a functional polypeptide chain.
Thus, the correct chronological sequence of these molecular events is (B) \( \rightarrow \) (C) \( \rightarrow \) (A) \( \rightarrow \) (D).
Step 3: Final Answer:
The correct sequence of eukaryotic gene expression is (B), (C), (A), (D), corresponding to option (A).
Gene expression in eukaryotes is spatially and temporally divided due to the compartmentalization of the cell.
Transcription and RNA processing occur within the nucleus, whereas translation of mature mRNA into a polypeptide chain occurs within the cytoplasm.
Step 2: Detailed Explanation:
Let us organize the steps of eukaryotic gene expression in chronological order:
1.
Step 1: Transcription (B): The enzyme RNA polymerase II transcribes the genomic DNA template in the nucleus to synthesize a primary RNA transcript, also known as pre-mRNA.
2. Co-transcriptional and Post-transcriptional Processing (C): The nascent pre-mRNA undergoes several modifications in the nucleus before it is functional:
- Addition of a 7-methylguanosine cap at the 5' end.
- Cleavage of the 3' end and addition of a polyadenylated (poly-A) tail.
- Splicing to remove non-coding introns and join coding exons, catalyzed by the spliceosome complex.
This generates a mature mRNA molecule.
3.
Step 2: Nucleocytoplasmic Export (A): The mature, fully processed mRNA is exported from the nucleus into the cytoplasm through the nuclear pore complexes.
4.
Step 3: Translation (D): In the cytoplasm, the mature mRNA binds to ribosomes, which translate the nucleotide sequence into a functional polypeptide chain.
Thus, the correct chronological sequence of these molecular events is (B) \( \rightarrow \) (C) \( \rightarrow \) (A) \( \rightarrow \) (D).
Step 3: Final Answer:
The correct sequence of eukaryotic gene expression is (B), (C), (A), (D), corresponding to option (A).
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