Concept:
Drug excretion is the removal of drugs and their metabolites from the body.
Step 1: The kidney is the major organ of drug excretion.
Step 2: Drugs are filtered through glomerular filtration.
Step 3: Some drugs undergo tubular secretion.
Step 4: Some drugs may also undergo tubular reabsorption.
Step 5: Finally, drugs and metabolites are removed through urine.
\[
\boxed{\text{Kidney}}
\]