Concept:
The time of collection of crude drugs is very important because active constituents vary with season and stage of plant growth.
Step 1: Understanding digitalis.
Digitalis leaves contain cardiac glycosides. These glycosides are responsible for the medicinal activity of digitalis.
Step 2: Best collection stage.
Digitalis leaves are collected during the flowering stage because the active constituent content is suitable at this stage.
Step 3: Why timing matters.
If leaves are collected too early or too late, the concentration of active glycosides may be lower, affecting drug quality.
Step 4: Checking other options.
Before flowering, after flowering, or fruiting stage are not the correct collection stages according to the given paper.
Step 5: Final answer.
Therefore, digitalis leaves should be collected during flowering stage.
\[
\boxed{\text{During flowering stage}}
\]