Question:
Complement components formed in the liver are?
Complement components formed in the liver are?
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The liver is the chief source of the central complement protein C3 and its partners.
Updated On: Jun 24, 2026
- C2, C4
- C3, C6, C9
- C5, C8
- C1
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The Correct Option is B
Solution and Explanation
Step 1: Complement proteins are synthesized at several body sites, and the question asks which set is made mainly in the liver. The liver (hepatocytes) is the principal source of most circulating complement components.
Step 2: Among the options, C3, C6 and C9 are the components produced chiefly in the liver, so option b is correct. C3 in particular is the central complement protein and is made in large amounts by hepatocytes.
Step 3: The distractors map to other production sites. C2 and C4 are made largely by macrophages, C5 and C8 are associated with the spleen, and C1 is produced mainly in the intestinal epithelium. These are not the liver set.
Step 4: Therefore the complement components formed in the liver are C3, C6 and C9.
Step 2: Among the options, C3, C6 and C9 are the components produced chiefly in the liver, so option b is correct. C3 in particular is the central complement protein and is made in large amounts by hepatocytes.
Step 3: The distractors map to other production sites. C2 and C4 are made largely by macrophages, C5 and C8 are associated with the spleen, and C1 is produced mainly in the intestinal epithelium. These are not the liver set.
Step 4: Therefore the complement components formed in the liver are C3, C6 and C9.
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