Question:
Cell-matrix adhesions are mediated by?
Cell-matrix adhesions are mediated by?
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Cadherins glue cell to cell; which family binds the matrix instead?
Updated On: Jun 24, 2026
- Cadherins
- Integrins
- Selectins
- Calmodulin
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The Correct Option is B
Solution and Explanation
Step 1: Cell adhesion molecules fall into broad families. Integrins bind components of the extracellular matrix such as fibronectin, laminin and collagen, so they are the principal molecules that anchor cells to the matrix.
Step 2: In focal adhesions and hemidesmosomes, integrins link the matrix on the outside to the actin or keratin cytoskeleton on the inside, making cell-matrix adhesion possible. Hence option b is correct.
Step 3: Cadherins are calcium-dependent molecules that mediate cell-to-cell adhesion in anchoring junctions, not cell-matrix contact. Selectins mediate the rolling of leukocytes on endothelium, and calmodulin is an intracellular calcium-binding signalling protein, so options a, c and d are wrong.
Step 2: In focal adhesions and hemidesmosomes, integrins link the matrix on the outside to the actin or keratin cytoskeleton on the inside, making cell-matrix adhesion possible. Hence option b is correct.
Step 3: Cadherins are calcium-dependent molecules that mediate cell-to-cell adhesion in anchoring junctions, not cell-matrix contact. Selectins mediate the rolling of leukocytes on endothelium, and calmodulin is an intracellular calcium-binding signalling protein, so options a, c and d are wrong.
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