Question:
An 11-year-old boy presented with cough for 15 days. On examination he was found to have cervical lymphadenopathy. Lymph node examination showed the finding below. What could be the diagnosis?
An 11-year-old boy presented with cough for 15 days. On examination he was found to have cervical lymphadenopathy. Lymph node examination showed the finding below. What could be the diagnosis?
Show Hint
A granuloma with central caseous necrosis and Langhans giant cells has one classic cause.
Updated On: Jun 23, 2026
- Leprosy
- Sarcoidosis
- TB
- Syphilis
Show Solution
Verified By Collegedunia
The Correct Option is C
Solution and Explanation
Step 1: A child with chronic cough and cervical lymphadenopathy in an endemic country strongly suggests tuberculous lymphadenitis (scrofula).
Step 2: The lymph node histology shows a granuloma with central caseous necrosis surrounded by epithelioid histiocytes and Langhans-type multinucleated giant cells. Caseating granulomas are the defining feature of tuberculosis.
Step 3: Differentiate from the distractors: sarcoidosis produces non-caseating (naked) granulomas, leprosy shows granulomas with nerve involvement and acid-fast bacilli on Fite stain, and syphilis gives plasma-cell-rich endarteritis with gummas. The caseating granuloma here points to TB caused by Mycobacterium tuberculosis.
Answer: TB.
Ref: Robbins Basic Pathology, 9e, p 493.
Step 2: The lymph node histology shows a granuloma with central caseous necrosis surrounded by epithelioid histiocytes and Langhans-type multinucleated giant cells. Caseating granulomas are the defining feature of tuberculosis.
Step 3: Differentiate from the distractors: sarcoidosis produces non-caseating (naked) granulomas, leprosy shows granulomas with nerve involvement and acid-fast bacilli on Fite stain, and syphilis gives plasma-cell-rich endarteritis with gummas. The caseating granuloma here points to TB caused by Mycobacterium tuberculosis.
Answer: TB.
Ref: Robbins Basic Pathology, 9e, p 493.
Was this answer helpful?
0
0
Top NEET PG Pathology Questions
- Which of the following is true regarding the Mendelian mode of inheritance?
- A child presents with intermittent jaundice and splenomegaly. There is a history of similar complaints in the elder brother. Peripheral smear shows the following finding. How will you investigate this condition?
- An African child is found to have a mass in the jaw. A biopsy of the mass was done, and it appears as shown in the image below. The child also had a translocation of t(8;14). What is the probable diagnosis?
- A child presented to the hospital with cola-colored urine, hypertension, and puffiness of eyes. Laboratory investigations were done, and creatinine was 2.5 mg/dL. Treatment was started, and despite treatment, the patient did not improve for the next 3 weeks. The creatinine value increased to 4.5 mg/dL. Which among the following electron microscopic findings will be seen in this patient ?
- A patient was transfused 4 units of blood 2 hours ago, and now she complains of chest discomfort. X-ray shows bilateral fissural thickening. Which of the following is the most probable cause ?
View More Questions
Top NEET PG Tuberculous lymphadenitis Questions
Top NEET PG Questions
- A patient hailing from Delhi presents with fever, arthralgia, and extensive petechial rash for 3 days. Lab investigations revealed a hemoglobin of 9 g/ dL, a white blood cell count of 9000 cells/mm3, a platelet count of 20000 cells/mm3, and a prolonged bleeding time. The clotting time was normal. What is the most likely diagnosis?
- Which of the following statements is true about Trichomonas vaginalis?
- A lady from West Rajasthan presented with an ulcer surrounded by erythema on the right leg. Microscopy of the biopsy from the edge of the ulcer showed organisms with dark staining nuclei and kinetoplast. What is the most likely causative agent?
- A child presents with a fever and a rash. Urine examination showed cells with owl's eye appearance. What is the most likely diagnosis?
- Infection with Clonorchis sinensis is associated with an increased risk of__?
View More Questions