Question

All trans retinoic acid is used in the treatment of tumour associated with

• A. BCR-ABL
• B. PML-RARA
• C. CMYC
• D. CEBPA

Answer 1

The Correct Option is B

All-trans retinoic acid is specifically used in the treatment of acute promyelocytic leukemia (APL), which is associated with the fusion protein PML-RARA. This fusion protein results from a characteristic chromosomal translocation t(15;17)(q24;q21). In APL, the PML-RARA fusion affects the retinoic acid receptor (RAR) signaling pathway, leading to a blockage in myeloid differentiation. All-trans retinoic acid works by binding to the RARA part of the fusion protein, which helps promote differentiation of the leukemic blasts into mature myeloid cells. This makes PML-RARA the targeted treatment with all-trans retinoic acid.

Options	Associated Condition
BCR-ABL	Chronic Myeloid Leukemia (CML)
PML-RARA	Acute Promyelocytic Leukemia (APL)
CMYC	Burkitt's Lymphoma
CEBPA	Certain types of acute myeloid leukemia (AML)

Therefore, the treatment of choice involving all-trans retinoic acid is accurate for conditions associated with PML-RARA fusion, making option PML-RARA the correct answer.