Question

Acetophenone can be prepared from which of the following reactants? 

• A. B, D only
• B. B, C, D only
• C. A, C, D only
• D. A, B, C only

Hint:

Acetophenone can be synthesized via Grignard reaction with nitriles or Friedel-Crafts acylation using acetyl anhydride or acetyl chloride in the presence of AlCl\(_3\).

Answer 1

The Correct Option is A

Acetophenone (C₆H₅COCH₃) is a ketone that can be synthesized by various methods. Let's analyze each given reactant:

1. Option A (Benzoyl Chloride + CH₃MgBr):
- Reaction with Grignard reagent would lead to a tertiary alcohol, not acetophenone.
- Incorrect for acetophenone synthesis.

2. Option B (Benzonitrile + CH₃MgBr, H₂O):
- Grignard reagents react with nitriles (-CN) to form ketones after hydrolysis.
- This is a correct method to form Acetophenone.

3. Option C (Benzoic Acid + CH₃COOH):
- No ketone formation occurs directly between benzoic acid and acetic acid.
- Incorrect method for Acetophenone synthesis.

4. Option D (Benzene + Acetyl Anhydride [(CH₃CO)₂O]):
- This is Friedel-Crafts Acylation, which forms acetophenone in the presence of AlCl₃.
- Correct method to form Acetophenone.

Thus, B and D are the correct choices.