Step 1: Yaws is a chronic non-venereal treponematosis (endemic treponematosis) of tropical regions.
Step 2: It is caused by Treponema pallidum subspecies pertenue (Treponema pertenue), so option A is true.
Step 3: Transmission is by direct skin-to-skin contact in childhood, not by sexual contact, so it is non-venereal and option B is true.
Step 4: Secondary yaws produces multiple skin lesions and can involve bones and joints (periostitis, dactylitis), so option C is true.
Step 5: Unlike venereal syphilis, yaws does NOT cause cardiovascular or neurological (heart and nerve) involvement. Gummatous destruction of skin and bone occurs in late yaws, but the cardiovascular and neurosyphilis-type complications are absent.
Conclusion: The false statement is option 4, so the correct answer is option 4, matching the printed key.