Question:
A patient with tumor lysis syndrome has elevated uric acid levels and is prescribed Pegloticase. What is the mechanism of action of Pegloticase?
A patient with tumor lysis syndrome has elevated uric acid levels and is prescribed Pegloticase. What is the mechanism of action of Pegloticase?
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Pegloticase is recombinant uricase; it oxidizes uric acid to soluble allantoin.
Updated On: May 14, 2026
- Xanthine oxidase inhibition
- URAT-1 receptor inhibition
- Oxidizes uric acid
- Hydrolysis of uric acid
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The Correct Option is C
Solution and Explanation
Concept:
Pegloticase is a recombinant uricase enzyme. It converts uric acid into allantoin, which is more soluble and easily excreted.
Step 1: Identify the drug type.
Pegloticase is an enzyme preparation with uricase-like activity.
Step 2: Recall its action.
It catalyzes oxidation of uric acid to: \[ \text{Allantoin} \]
Step 3: Choose the mechanism.
Since it converts uric acid by oxidation, the correct mechanism is: \[ \text{Oxidizes uric acid} \] Therefore, the correct answer is Oxidizes uric acid.
Step 1: Identify the drug type.
Pegloticase is an enzyme preparation with uricase-like activity.
Step 2: Recall its action.
It catalyzes oxidation of uric acid to: \[ \text{Allantoin} \]
Step 3: Choose the mechanism.
Since it converts uric acid by oxidation, the correct mechanism is: \[ \text{Oxidizes uric acid} \] Therefore, the correct answer is Oxidizes uric acid.
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