Which antitubercular drug inhibits the action of OCPs?
- Rifampicin
- Ethambutol
- Isoniazid
- Pyrazinamide
The Correct Option is A
Solution and Explanation
To determine which antitubercular drug inhibits the action of oral contraceptive pills (OCPs), we need to understand the interaction between these drugs and enzyme induction pathways in the liver.
Rifampicin, a commonly used antitubercular drug, is known to be a potent inducer of cytochrome P450 (CYP) enzymes, specifically CYP3A4. This enzyme induction increases the metabolism of various drugs, including the hormones found in oral contraceptives. As a result, the effectiveness of the OCPs is reduced, which may lead to contraceptive failure.
In contrast, Ethambutol, Isoniazid, and Pyrazinamide do not have significant enzyme-inducing effects and thus do not notably affect the efficacy of oral contraceptives.
Therefore, the drug that inhibits the action of OCPs by inducing their metabolism is Rifampicin.
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