Question

A girl child has had recurrent yeast and respiratory virus infections since she was 3 months old. Now considering studies for immune status, which vaccine is contraindicated?

• A. TT/Td
• B. Measles/MMR
• C. DPT
• D. Killed IPV

Hint:

Identify whether the child is immunocompromised, then recall which vaccine types are contraindicated in immunodeficiency states.

Answer 1

The Correct Option is B

Step 1: Identify the underlying condition. A girl with recurrent yeast infections and recurrent respiratory viral infections since 3 months of age has an underlying immunodeficiency. This pattern -- combined susceptibility to fungal (yeast) and viral pathogens from early infancy -- is suggestive of Combined Immunodeficiency (CID) or Severe Combined Immunodeficiency (SCID) involving both T-cell and humoral (B-cell) defects.

Step 2: Recall vaccine contraindications in immunocompromised patients. In immunocompromised individuals, live attenuated vaccines are contraindicated because the attenuated pathogen can cause disease in a host that cannot mount an effective immune response.

Step 3: Classify each option.
- TT/Td: Toxoid (inactivated) -- safe in immunocompromised
- Measles/MMR: Live attenuated vaccine -- CONTRAINDICATED
- DPT: Inactivated/toxoid -- safe in immunocompromised
- Killed IPV: Inactivated polio vaccine -- safe in immunocompromised

Step 4: Conclusion. MMR (Measles, Mumps, Rubella) is a live attenuated vaccine. Administering it to an immunocompromised child risks vaccine-strain infection. It is therefore contraindicated.

Conclusion: The correct answer is Option B -- Measles/MMR.