Question:
A drug with high plasma protein binding property has which of the following properties?
A drug with high plasma protein binding property has which of the following properties?
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Only free drug is filtered at the glomerulus.
Updated On: Jun 23, 2026
- Less GFR
- Less drug interaction
- Higher volume of distribution
- Less tubular secretion
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The Correct Option is A
Solution and Explanation
Step 1: Plasma protein binding (PPB) keeps a fraction of the drug bound to albumin and other proteins. Only the free, unbound drug is pharmacologically active and available for filtration.
Step 2: Glomerular filtration handles only free drug. A highly protein bound drug has little free drug, so the amount filtered through the glomerulus is small. This means a highly bound drug shows lesser glomerular filtration, making option a correct.
Step 3: Tubular secretion is an energy requiring, carrier mediated active transport that can strip drug off the protein, so high PPB does not reduce tubular secretion. Option d is wrong.
Step 4: High PPB actually increases drug interactions (displacement) so option b is wrong, and it tends to keep the drug in plasma giving a lower, not higher, volume of distribution, so option c is wrong.
Step 2: Glomerular filtration handles only free drug. A highly protein bound drug has little free drug, so the amount filtered through the glomerulus is small. This means a highly bound drug shows lesser glomerular filtration, making option a correct.
Step 3: Tubular secretion is an energy requiring, carrier mediated active transport that can strip drug off the protein, so high PPB does not reduce tubular secretion. Option d is wrong.
Step 4: High PPB actually increases drug interactions (displacement) so option b is wrong, and it tends to keep the drug in plasma giving a lower, not higher, volume of distribution, so option c is wrong.
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