Question:
A boy presents with multiple non-suppurative osteomyelitis along with sickle cell anaemia. What is the most likely causative organism?
A boy presents with multiple non-suppurative osteomyelitis along with sickle cell anaemia. What is the most likely causative organism?
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Sickle cell plus osteomyelitis equals which organism?
Updated On: Jun 24, 2026
- Salmonella
- S. aureus
- H. influenzae
- Enterobacter species
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The Correct Option is A
Solution and Explanation
Step 1: Osteomyelitis has different common organisms by patient group. In the general population, Staphylococcus aureus is the most frequent cause across most age groups.
Step 2: However, in patients with sickle cell disease, Salmonella species are characteristically the most common cause of osteomyelitis, so option 1 is correct.
Step 3: The combination of sickle cell anaemia and multiple bone involvement strongly points to Salmonella in this scenario.
Step 4: S. aureus, H. influenzae, and Enterobacter are important in other settings (neonates, children, adults) but are not the classic sickle-cell association, so options 2, 3, and 4 are wrong here.
Step 2: However, in patients with sickle cell disease, Salmonella species are characteristically the most common cause of osteomyelitis, so option 1 is correct.
Step 3: The combination of sickle cell anaemia and multiple bone involvement strongly points to Salmonella in this scenario.
Step 4: S. aureus, H. influenzae, and Enterobacter are important in other settings (neonates, children, adults) but are not the classic sickle-cell association, so options 2, 3, and 4 are wrong here.
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