Question

A 30-year-old male came with complaints of swelling around the knee joint. Histopathological examination of the swelling demonstrated many giant cells interspersed with mononuclear cells. What is the probable diagnosis ?

• A. Osteosarcoma
• B. Ewing's sarcoma
• C. Giant cell tumour
• D. Chondrosarcoma

Answer 1

The Correct Option is C

The clinical presentation involves a 30-year-old male with a knee joint swelling. Histopathological findings reveal many giant cells among mononuclear cells. This pattern is indicative of a Giant Cell Tumour (GCT). Giant Cell Tumor of the bone, also known as osteoclastoma, typically occurs around the knee joint, especially in young adults. The presence of giant cells intermixed with mononuclear cells is characteristic of this tumor.

Condition	Features
Osteosarcoma	Often presents with osteoid production by malignant cells, typically in adolescents, not primarily giant cells
Ewing's sarcoma	Small round blue cell tumor, typically affects younger patients, characterized by 'onion skin' periosteal reaction
Giant cell tumor	Giant cells with mononuclear stromal cells, typically near the knee in young adults
Chondrosarcoma	Usually occurs in older adults, characterized by cartilage matrix production

Given the age, location, and histopathological findings, the most probable diagnosis is Giant Cell Tumour.