Question:
Zero-order kinetics is otherwise known as saturation kinetics. It is independent of:
Zero-order kinetics is otherwise known as saturation kinetics. It is independent of:
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If a fixed amount leaves per unit time, the rate cannot depend on how much is in the plasma.
Updated On: Jun 23, 2026
- Plasma concentration
- Clearance
- Volume of distribution
- Half life
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The Correct Option is A
Solution and Explanation
Step 1: In zero-order (saturation) kinetics the eliminating enzymes or transporters are saturated, so they work at maximum fixed capacity.
Step 2: As a result, a constant AMOUNT of drug is removed per unit time, no matter how high the plasma level rises. The rate of elimination is therefore independent of plasma concentration. Option A is correct.
Step 3: Why the others vary: in zero-order kinetics clearance and half-life are not constant; they change with the drug concentration (half-life lengthens as concentration rises), so they cannot be the concentration-independent quantity. Volume of distribution is a separate distribution parameter, not the feature this question tests. Classic examples include ethanol, phenytoin (at high dose), and aspirin.
Ref: standard pharmacokinetics texts on zero-order elimination.
Step 2: As a result, a constant AMOUNT of drug is removed per unit time, no matter how high the plasma level rises. The rate of elimination is therefore independent of plasma concentration. Option A is correct.
Step 3: Why the others vary: in zero-order kinetics clearance and half-life are not constant; they change with the drug concentration (half-life lengthens as concentration rises), so they cannot be the concentration-independent quantity. Volume of distribution is a separate distribution parameter, not the feature this question tests. Classic examples include ethanol, phenytoin (at high dose), and aspirin.
Ref: standard pharmacokinetics texts on zero-order elimination.
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