Question

Which receptor does Benralizumab act on?

• A. IL-5
• B. IL-4
• C. IL-1
• D. TNF-$\alpha$

Hint:

Benralizumab targets the IL-5 receptor; mepolizumab and reslizumab target IL-5 itself.

Answer 1

The Correct Option is A

Concept: Benralizumab is a monoclonal antibody used in severe eosinophilic asthma. It targets the IL-5 receptor alpha subunit on eosinophils and basophils.

Step 1: Identify the drug class.
Benralizumab is a biologic monoclonal antibody used for eosinophilic asthma.

Step 2: Recall its target.
Benralizumab acts against: \[ \text{IL-5 receptor} \] This reduces eosinophil survival and activity.

Step 3: Choose the best option.
Among the given options, IL-5 is the correct target pathway. Therefore, the correct answer is IL-5.