Step 1: Recall what each lesion is.
Salmon patch, also called nevus simplex, is a flat pink birthmark usually on the eyelids, glabella, or nape of the neck. Strawberry angioma, an infantile hemangioma, is a raised red vascular tumor. Portwine stain, also called nevus flammeus, is a flat, permanent capillary malformation. Lymphangiomatosis circumscripta is a cluster of small fluid filled vesicles from malformed lymph channels.
Step 2: Check the course of salmon patch.
A salmon patch on the eyelids or glabella usually fades within the first year of life. Patches on the nape of the neck may linger longer but often lighten. So this lesion does regress, at least in part.
Step 3: Check the course of strawberry angioma.
Infantile hemangiomas grow for the first few months, then slowly shrink over several years. By age 5 to 10 years, most have shrunk greatly or gone completely. So this lesion regresses.
Step 4: Check the course of portwine stain.
A portwine stain is a true vascular malformation, not a tumor. It is present at birth and stays for life. With age it usually darkens and can thicken, it never fades on its own.
Step 5: Check the course of lymphangiomatosis circumscripta.
This is also a malformation of lymph vessels and tends to persist, but among the four choices, portwine stain is the textbook example of a lesion that never regresses.
Final Answer:
Portwine stain is the lesion that does not regress.