Question:
Which of the following statements is incorrect with respect to prasugrel?
Which of the following statements is incorrect with respect to prasugrel?
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Prasugrel, like clopidogrel, must be activated - so it IS a prodrug.
Updated On: Jun 24, 2026
- Not a prodrug
- P2Y purinergic receptor blocker
- Has a strong antiplatelet activity
- Causes intracranial haemorrhage in TIA patients
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The Correct Option is A
Solution and Explanation
Step 1: This is a negative-stem question - find the statement that is FALSE about prasugrel.
Step 2: Prasugrel IS a prodrug, like clopidogrel; it belongs to the thienopyridine class and must be metabolically activated. So the statement "Not a prodrug" is incorrect - option (a) - and is the answer.
Step 3: The other statements are true: prasugrel is an irreversible antagonist of P2Y12 ADP (purinergic) receptors (b); it is rapidly absorbed, completely activated, gives consistent platelet inhibition and thus strong antiplatelet activity (c); and it carries serious bleeding risk and is contraindicated in patients with a history of ischaemic stroke/TIA because of intracranial haemorrhage risk (d).
Step 4: Hence the incorrect statement, and the correct choice, is (a) "Not a prodrug."
Step 2: Prasugrel IS a prodrug, like clopidogrel; it belongs to the thienopyridine class and must be metabolically activated. So the statement "Not a prodrug" is incorrect - option (a) - and is the answer.
Step 3: The other statements are true: prasugrel is an irreversible antagonist of P2Y12 ADP (purinergic) receptors (b); it is rapidly absorbed, completely activated, gives consistent platelet inhibition and thus strong antiplatelet activity (c); and it carries serious bleeding risk and is contraindicated in patients with a history of ischaemic stroke/TIA because of intracranial haemorrhage risk (d).
Step 4: Hence the incorrect statement, and the correct choice, is (a) "Not a prodrug."
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