Question:
Which of the following should be monitored in a patient receiving linezolid therapy?
Which of the following should be monitored in a patient receiving linezolid therapy?
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Long courses of this oxazolidinone suppress the marrow.
Updated On: Jun 24, 2026
- Renal function
- Liver function
- Auditory function
- Platelet count
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The Correct Option is D
Solution and Explanation
Step 1: Linezolid is an oxazolidinone antibiotic used against resistant gram-positive organisms such as MRSA and VRE.
Step 2: Its most important dose-limiting toxicity is myelosuppression, especially thrombocytopenia, which becomes prominent with prolonged use beyond about two weeks. Hence the platelet count (along with the full blood count) must be monitored. Option D is correct.
Step 3: Linezolid is not classically nephrotoxic, so routine renal monitoring is not the key concern. Option A is not the best answer.
Step 4: Hepatotoxicity is not the hallmark adverse effect that drives monitoring. Option B is not the best answer.
Step 5: Auditory (ototoxic) monitoring is needed for aminoglycosides and vancomycin, not for linezolid. Option C is wrong.
Conclusion: The parameter to monitor on linezolid therapy is the platelet count, option D.
Step 2: Its most important dose-limiting toxicity is myelosuppression, especially thrombocytopenia, which becomes prominent with prolonged use beyond about two weeks. Hence the platelet count (along with the full blood count) must be monitored. Option D is correct.
Step 3: Linezolid is not classically nephrotoxic, so routine renal monitoring is not the key concern. Option A is not the best answer.
Step 4: Hepatotoxicity is not the hallmark adverse effect that drives monitoring. Option B is not the best answer.
Step 5: Auditory (ototoxic) monitoring is needed for aminoglycosides and vancomycin, not for linezolid. Option C is wrong.
Conclusion: The parameter to monitor on linezolid therapy is the platelet count, option D.
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