Question:
Which of the following metabolite(s) accumulate(s) in the blood of a human adult consuming a ketogenic diet?
Which of the following metabolite(s) accumulate(s) in the blood of a human adult consuming a ketogenic diet?
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A ketogenic diet increases the production of ketone bodies like D-β-hydroxybutyrate and acetoacetate, which provide an alternative energy source to glucose.
Updated On: Sep 8, 2025
- D-β-hydroxybutyrate
- Acetoacetate
- Pyruvate
- Oxaloacetate
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The Correct Option is A, B
Solution and Explanation
Step 1: Understanding the metabolic effects of a ketogenic diet.
A ketogenic diet promotes the production of ketone bodies from fatty acids. These ketone bodies are used as an alternative energy source when glucose is limited.
Step 2: Analyzing the options.
- (A) Correct: D-β-hydroxybutyrate is one of the primary ketone bodies produced during ketosis, and its levels accumulate in the blood during a ketogenic diet.
- (B) Correct: Acetoacetate is another ketone body that accumulates in the blood during a ketogenic diet, serving as a source of energy for tissues like the brain.
- (C) Incorrect: Pyruvate is a key intermediate in glucose metabolism but does not accumulate during a ketogenic diet. In fact, its production is reduced in favor of ketone bodies.
- (D) Incorrect: Oxaloacetate is involved in gluconeogenesis and is not a product of ketogenesis. Its levels are typically low during a ketogenic diet.
Final Answer: \[ \boxed{\text{(A) and (B) are correct.}} \]
A ketogenic diet promotes the production of ketone bodies from fatty acids. These ketone bodies are used as an alternative energy source when glucose is limited.
Step 2: Analyzing the options.
- (A) Correct: D-β-hydroxybutyrate is one of the primary ketone bodies produced during ketosis, and its levels accumulate in the blood during a ketogenic diet.
- (B) Correct: Acetoacetate is another ketone body that accumulates in the blood during a ketogenic diet, serving as a source of energy for tissues like the brain.
- (C) Incorrect: Pyruvate is a key intermediate in glucose metabolism but does not accumulate during a ketogenic diet. In fact, its production is reduced in favor of ketone bodies.
- (D) Incorrect: Oxaloacetate is involved in gluconeogenesis and is not a product of ketogenesis. Its levels are typically low during a ketogenic diet.
Final Answer: \[ \boxed{\text{(A) and (B) are correct.}} \]
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