Question:
Which of the following is true about lamotrigine?
Which of the following is true about lamotrigine?
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Once-daily dosing reflects a roughly 24 hour half-life; it is not first line for absence.
Updated On: Jun 24, 2026
- Decreased efficacy in depression
- First choice in absence seizure
- t1/2 is 24 hours
- Not metabolised in liver
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The Correct Option is C
Solution and Explanation
Step 1: Lamotrigine is a broad-spectrum antiepileptic that blocks voltage-gated sodium channels and reduces glutamate release. It has an elimination half-life of roughly 24 to 30 hours, allowing once or twice daily dosing. This makes option (c) correct.
Step 2: Lamotrigine is mood-stabilising and is actually effective in bipolar depression, so the statement that it has decreased efficacy in depression (a) is false.
Step 3: The first-line drug for absence seizures is ethosuximide (or valproate). Lamotrigine is an alternative, not the first choice, so option (b) is wrong.
Step 4: Lamotrigine IS metabolised in the liver, mainly by glucuronide conjugation, so option (d) is false. By elimination and by direct fact, the correct answer is its half-life of about 24 hours.
Step 2: Lamotrigine is mood-stabilising and is actually effective in bipolar depression, so the statement that it has decreased efficacy in depression (a) is false.
Step 3: The first-line drug for absence seizures is ethosuximide (or valproate). Lamotrigine is an alternative, not the first choice, so option (b) is wrong.
Step 4: Lamotrigine IS metabolised in the liver, mainly by glucuronide conjugation, so option (d) is false. By elimination and by direct fact, the correct answer is its half-life of about 24 hours.
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