Step 1: Heart sounds can be grouped by pitch. High pitched sounds include the mid systolic click, opening snap and the pericardial knock or shudder. Low pitched sounds include S3, S4 and the tumour plop. The question asks for the one that is NOT high pitched, so the answer is option d, the tumour plop.
Step 2: The mid systolic click is heard in mitral valve prolapse during systole and is a high pitched sound.
Step 3: The opening snap and the pericardial knock are high pitched and occur in early diastole; the pericardial knock is a feature of constrictive pericarditis.
Step 4: A tumour plop is a lower pitched diastolic sound heard in atrial myxoma, arising as the tumour prolapses across the mitral valve. Being low pitched, it is the correct exception.