Question:
Which of the following is NOT a disorder of protein misfolding?
Which of the following is NOT a disorder of protein misfolding?
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Three are conformational diseases; one is a bacterial infection.
Updated On: Jun 24, 2026
- Alzheimer's disease
- Tuberculosis
- Cystic fibrosis
- Creutzfeldt-Jakob disease (CJD)
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The Correct Option is B
Solution and Explanation
Step 1: Define protein misfolding disorders (proteinopathies). These are diseases in which a protein adopts an abnormal three-dimensional conformation, leading to loss of function or toxic aggregation.
Step 2: Classify each option. Alzheimer's disease involves misfolded amyloid-beta and hyperphosphorylated tau aggregates, so it is a proteinopathy. CJD is caused by the misfolded prion protein (PrPSc), a classic protein-misfolding disease. Cystic fibrosis is caused by the delta-F508 CFTR mutation in which the CFTR protein misfolds and is degraded before reaching the cell membrane, so it is also a misfolding disorder.
Step 3: Identify the exception. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Its pathology is microbial infection and granulomatous inflammation, not protein misfolding.
Step 4: Conclusion. The odd one out is tuberculosis.
The medically correct and printed answer is option 2 (Tuberculosis).
Step 2: Classify each option. Alzheimer's disease involves misfolded amyloid-beta and hyperphosphorylated tau aggregates, so it is a proteinopathy. CJD is caused by the misfolded prion protein (PrPSc), a classic protein-misfolding disease. Cystic fibrosis is caused by the delta-F508 CFTR mutation in which the CFTR protein misfolds and is degraded before reaching the cell membrane, so it is also a misfolding disorder.
Step 3: Identify the exception. Tuberculosis is an infectious disease caused by Mycobacterium tuberculosis. Its pathology is microbial infection and granulomatous inflammation, not protein misfolding.
Step 4: Conclusion. The odd one out is tuberculosis.
The medically correct and printed answer is option 2 (Tuberculosis).
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