Question:
Which of the following is associated with peripheral artery disease, coronary heart disease and stroke?
Which of the following is associated with peripheral artery disease, coronary heart disease and stroke?
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All three are atherosclerotic diseases, and diabetes is the strong shared risk.
Updated On: Jun 24, 2026
- Insulin deficiency
- Hyperestrogenemia
- Hypothyroidism
- Hyperprogesteronemia
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The Correct Option is A
Solution and Explanation
Step 1: Peripheral artery disease, coronary heart disease, and stroke are all atherosclerotic vascular diseases. The question asks which listed state drives widespread atherosclerosis.
Step 2: Insulin deficiency means diabetes mellitus. Diabetes is one of the strongest risk factors for atherosclerosis across all arterial beds, causing coronary disease, peripheral artery disease, and ischemic stroke through high glucose, dyslipidemia, and endothelial damage. So option A is the best fit and matches the printed key.
Step 3: Why not the others. Estrogen is generally vascular-protective in premenopausal women, so hyperestrogenemia does not drive this triad (B is wrong). Hypothyroidism can raise lipids but is not the classic single answer for this combined atherosclerotic triad (C is less appropriate). Progesterone excess is not a recognised cause of this combination (D is wrong).
Step 4: The condition tying together peripheral artery disease, coronary heart disease, and stroke is diabetes from insulin deficiency.
Correct option: A.
Step 2: Insulin deficiency means diabetes mellitus. Diabetes is one of the strongest risk factors for atherosclerosis across all arterial beds, causing coronary disease, peripheral artery disease, and ischemic stroke through high glucose, dyslipidemia, and endothelial damage. So option A is the best fit and matches the printed key.
Step 3: Why not the others. Estrogen is generally vascular-protective in premenopausal women, so hyperestrogenemia does not drive this triad (B is wrong). Hypothyroidism can raise lipids but is not the classic single answer for this combined atherosclerotic triad (C is less appropriate). Progesterone excess is not a recognised cause of this combination (D is wrong).
Step 4: The condition tying together peripheral artery disease, coronary heart disease, and stroke is diabetes from insulin deficiency.
Correct option: A.
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