Question:
Which of the following is/are true about colchicine?
Which of the following is/are true about colchicine?
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Colchicine is a tubulin binder with all the listed effects.
Updated On: Jun 23, 2026
- Acts by neutrophil recruitment
- Causes metaphase arrest
- Useful in urate-lowering therapy
- All of the above
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The Correct Option is D
Solution and Explanation
Step 1: Colchicine is an anti-gout drug that binds tubulin and prevents its polymerization into microtubules.
Step 2: It inhibits granulocyte migration into the inflamed joint. Depolymerization of microtubules alters neutrophil motility and affects neutrophil recruitment to inflamed tissue, and it reduces the secretion of chemotactic factors and superoxide anions. So statement a is true.
Step 3: By disrupting the mitotic spindle, colchicine arrests dividing cells in metaphase, so statement b is true.
Step 4: Daily colchicine is used as urate-lowering associated prophylaxis to suppress acute attacks precipitated by abrupt changes in serum uric acid, so statement c is true. Since all three statements are correct, option d (all of the above) is the answer. Its most common dose limiting toxicity is diarrhea.
Step 2: It inhibits granulocyte migration into the inflamed joint. Depolymerization of microtubules alters neutrophil motility and affects neutrophil recruitment to inflamed tissue, and it reduces the secretion of chemotactic factors and superoxide anions. So statement a is true.
Step 3: By disrupting the mitotic spindle, colchicine arrests dividing cells in metaphase, so statement b is true.
Step 4: Daily colchicine is used as urate-lowering associated prophylaxis to suppress acute attacks precipitated by abrupt changes in serum uric acid, so statement c is true. Since all three statements are correct, option d (all of the above) is the answer. Its most common dose limiting toxicity is diarrhea.
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