Question:
Which of the following is an orally active direct factor Xa inhibitor?
Which of the following is an orally active direct factor Xa inhibitor?
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Look for the oral "-xaban" drug, not the "-gatran" thrombin blocker.
Updated On: Jun 23, 2026
- Rivaroxaban
- Argatroban
- Dabigatran
- Bivalirudin
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The Correct Option is A
Solution and Explanation
Step 1: The question asks for an oral anticoagulant that directly blocks activated factor X (factor Xa) in the coagulation cascade.
Step 2: Rivaroxaban is an orally active direct factor Xa inhibitor. Apixaban and edoxaban belong to the same class of oral direct Xa inhibitors.
Step 3: The distractors act differently. Dabigatran (given orally as dabigatran etexilate) is a direct thrombin (factor IIa) inhibitor, not a Xa inhibitor. Argatroban and bivalirudin are parenteral direct thrombin inhibitors, not oral and not Xa inhibitors.
Step 4: Therefore, the only orally active direct factor Xa inhibitor among the options is Rivaroxaban.
Step 2: Rivaroxaban is an orally active direct factor Xa inhibitor. Apixaban and edoxaban belong to the same class of oral direct Xa inhibitors.
Step 3: The distractors act differently. Dabigatran (given orally as dabigatran etexilate) is a direct thrombin (factor IIa) inhibitor, not a Xa inhibitor. Argatroban and bivalirudin are parenteral direct thrombin inhibitors, not oral and not Xa inhibitors.
Step 4: Therefore, the only orally active direct factor Xa inhibitor among the options is Rivaroxaban.
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