Question

Which of the following feature(s) should be present in a protein to generate strong immune response (antibody production) in an animal?
I. At least one B-cell epitope
II. At least one T-cell epitope
III. Proteolytic cleavage site(s)

• A. I only
• B. II and III
• C. I and III
• D. I, II and III

Hint:

For effective antibody production, a protein should contain both B-cell and T-cell epitopes, and proteolytic cleavage sites for proper presentation.

Answer 1

The Correct Option is D

Step 1: Understanding Immune Response.
For a protein to generate an immune response, it must be recognized by the immune system. This recognition involves epitopes, which are specific regions of the protein that are recognized by antibodies or T-cell receptors.

Step 2: Analyzing the options.
(I) At least one B-cell epitope: Correct — B-cell epitopes are recognized by antibodies and trigger an immune response.
(II) At least one T-cell epitope: Correct — T-cell epitopes are important for the activation of T-cells, which also play a critical role in immune responses.
(III) Proteolytic cleavage site(s): Correct — Proteolytic cleavage of the protein can be crucial for presenting epitopes to the immune system.

Step 3: Conclusion.
The correct answer is (D) I, II and III, as all of these features contribute to a strong immune response.