Question:
Which of the following causes increased renin on prolonged use?
Which of the following causes increased renin on prolonged use?
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Blocking angiotensin II removes its negative feedback, so renin secretion rises.
Updated On: Jun 24, 2026
- Clonidine
- Enalapril
- Methyldopa
- Beta blocker
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The Correct Option is B
Solution and Explanation
Step 1: Enalapril is an ACE inhibitor. It blocks the conversion of angiotensin I to angiotensin II, so circulating angiotensin II falls.
Step 2: Angiotensin II normally exerts negative feedback on the juxtaglomerular cells. When angiotensin II is low, this brake is removed, so renin secretion rises. Plasma renin activity is therefore high on prolonged ACE inhibitor therapy.
Step 3: Hence enalapril is the answer.
Step 4: The distractors lower renin: clonidine and methyldopa are central sympatholytics that reduce renal sympathetic drive, and beta blockers block the beta-1 receptors on juxtaglomerular cells, both reducing renin release.
Step 2: Angiotensin II normally exerts negative feedback on the juxtaglomerular cells. When angiotensin II is low, this brake is removed, so renin secretion rises. Plasma renin activity is therefore high on prolonged ACE inhibitor therapy.
Step 3: Hence enalapril is the answer.
Step 4: The distractors lower renin: clonidine and methyldopa are central sympatholytics that reduce renal sympathetic drive, and beta blockers block the beta-1 receptors on juxtaglomerular cells, both reducing renin release.
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