Question:
Which of the following anticoagulants is given orally?
Which of the following anticoagulants is given orally?
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Look for the oral DOAC that blocks factor Xa.
Updated On: Jun 24, 2026
- Argatroban
- Alteplase
- Rivaroxaban
- Fondaparinux
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The Correct Option is C
Solution and Explanation
Step 1: The question asks which agent is active by the oral route. Most newer anticoagulants are parenteral; only the direct factor Xa and direct thrombin inhibitors of the DOAC class are oral.
Step 2: Rivaroxaban is an orally active direct inhibitor of activated factor Xa. It is used for prophylaxis and treatment of deep vein thrombosis and for stroke prevention in atrial fibrillation, so it is the correct answer.
Step 3: Alteplase is a thrombolytic (tissue plasminogen activator) given by intravenous infusion because of its very short half life of about 4 to 8 minutes, and it often needs heparin coadministration.
Step 4: Argatroban is a direct thrombin inhibitor given by IV infusion, used in heparin induced thrombocytopenia. Fondaparinux is a synthetic factor Xa inhibitor given subcutaneously with nearly 100 percent bioavailability. None of these three is oral, so Rivaroxaban stands out.
Step 2: Rivaroxaban is an orally active direct inhibitor of activated factor Xa. It is used for prophylaxis and treatment of deep vein thrombosis and for stroke prevention in atrial fibrillation, so it is the correct answer.
Step 3: Alteplase is a thrombolytic (tissue plasminogen activator) given by intravenous infusion because of its very short half life of about 4 to 8 minutes, and it often needs heparin coadministration.
Step 4: Argatroban is a direct thrombin inhibitor given by IV infusion, used in heparin induced thrombocytopenia. Fondaparinux is a synthetic factor Xa inhibitor given subcutaneously with nearly 100 percent bioavailability. None of these three is oral, so Rivaroxaban stands out.
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