Question:
Which is the most common malignancy associated with rheumatoid arthritis?
Which is the most common malignancy associated with rheumatoid arthritis?
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Think of the malignancy that overlaps with Felty syndrome in RA.
Updated On: Jun 24, 2026
- Diffuse large B cell lymphoma
- Large granular lymphocytic leukemia
- Chronic lymphocytic leukemia
- None of the above
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The Correct Option is B
Solution and Explanation
Step 1: Rheumatoid arthritis (RA) is a chronic immune-mediated disease driven by sustained lymphoid proliferation. This persistent stimulation of T and B cells slightly raises the long-term risk of lymphoproliferative disorders.
Step 2: The lymphoproliferative disorder most characteristically linked with RA is large granular lymphocytic (LGL) leukemia. It is a clonal expansion of cytotoxic T cells or NK cells and is part of the spectrum that overlaps with Felty syndrome (RA, splenomegaly, neutropenia).
Step 3: A minority of patients with chronic lymphoid proliferation related to RA evolve into frank LGL leukemia, which can worsen the neutropenia and recurrent infections seen in these patients. Hence option B is correct.
Step 4: Diffuse large B cell lymphoma and chronic lymphocytic leukemia are general lymphoid malignancies but are not the classic RA-specific association, so they are less appropriate answers.
Step 2: The lymphoproliferative disorder most characteristically linked with RA is large granular lymphocytic (LGL) leukemia. It is a clonal expansion of cytotoxic T cells or NK cells and is part of the spectrum that overlaps with Felty syndrome (RA, splenomegaly, neutropenia).
Step 3: A minority of patients with chronic lymphoid proliferation related to RA evolve into frank LGL leukemia, which can worsen the neutropenia and recurrent infections seen in these patients. Hence option B is correct.
Step 4: Diffuse large B cell lymphoma and chronic lymphocytic leukemia are general lymphoid malignancies but are not the classic RA-specific association, so they are less appropriate answers.
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