Step 1: The cerebral hemisphere is supplied by three paired cerebral arteries derived from the circle of Willis: the anterior, middle, and posterior cerebral arteries.
Step 2: The middle cerebral artery is the largest branch of the internal carotid artery. It runs in the lateral sulcus and supplies most of the lateral (superolateral) surface of the cerebral hemisphere, including the motor and sensory cortex for the upper limb, trunk, and face.
Step 3: The anterior cerebral artery supplies the medial surface and the small upper strip of the lateral surface, while the posterior cerebral artery supplies the occipital lobe and the inferior surface of the temporal lobe. The posterior inferior cerebellar artery supplies the cerebellum and medulla, not the cerebrum.
Step 4: Because it dominates the lateral surface, the middle cerebral artery is the chief artery of the lateral surface of the cerebral hemisphere.