Question:
Which drug decreases the bone resorption in osteoporosis?
Which drug decreases the bone resorption in osteoporosis?
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Look for the bisphosphonate that acts on osteoclasts, not the PTH analogue.
Updated On: Jun 23, 2026
- Teriparatide
- Risedronate
- Cortisone
- Cimetidine
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Verified By Collegedunia
The Correct Option is B
Solution and Explanation
Step 1: The question asks for an anti-resorptive agent. Risedronate is an aminobisphosphonate used for prevention and treatment of osteoporosis.
Step 2: Bisphosphonates bind to bone hydroxyapatite and act on osteoclasts and their precursors, inhibiting the dissolution (resorption) of bone and reducing bone remodelling.
Step 3: Teriparatide is a recombinant PTH analogue that is anabolic - it builds new bone rather than primarily decreasing resorption, so it is the distractor of choice in severe cases but is not an anti-resorptive.
Step 4: Cortisone (a glucocorticoid) actually worsens bone loss and causes osteoporosis, and cimetidine (an H2 blocker) has no anti-resorptive action. Therefore risedronate is the answer.
Step 2: Bisphosphonates bind to bone hydroxyapatite and act on osteoclasts and their precursors, inhibiting the dissolution (resorption) of bone and reducing bone remodelling.
Step 3: Teriparatide is a recombinant PTH analogue that is anabolic - it builds new bone rather than primarily decreasing resorption, so it is the distractor of choice in severe cases but is not an anti-resorptive.
Step 4: Cortisone (a glucocorticoid) actually worsens bone loss and causes osteoporosis, and cimetidine (an H2 blocker) has no anti-resorptive action. Therefore risedronate is the answer.
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