Question:
Which combination of chemotherapy agents is used for retinoblastoma?
Which combination of chemotherapy agents is used for retinoblastoma?
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Remember the VEC trio: Vincristine, Etoposide, Carboplatin.
Updated On: Jun 23, 2026
- Vincristine, carboplatin and etoposide
- Vinblastine, etoposide and bleomycin
- Vinblastine, vincristine and etoposide
- Vinblastine, vincristine and cisplatin
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The Correct Option is A
Solution and Explanation
Step 1: Retinoblastoma is the most common primary intraocular malignancy of childhood, and systemic chemotherapy (chemoreduction) is a mainstay of management, often combined with focal therapy.
Step 2: The standard, most widely used regimen is the triple combination of carboplatin, vincristine and etoposide (the VEC regimen). For very small tumours, carboplatin and vincristine alone may suffice.
Step 3: Option (a) lists exactly vincristine, carboplatin and etoposide, matching the standard regimen.
Step 4: The other options substitute vinblastine, bleomycin or cisplatin, which are not the standard retinoblastoma combination, so they are incorrect. The answer is option (a).
Step 2: The standard, most widely used regimen is the triple combination of carboplatin, vincristine and etoposide (the VEC regimen). For very small tumours, carboplatin and vincristine alone may suffice.
Step 3: Option (a) lists exactly vincristine, carboplatin and etoposide, matching the standard regimen.
Step 4: The other options substitute vinblastine, bleomycin or cisplatin, which are not the standard retinoblastoma combination, so they are incorrect. The answer is option (a).
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