Question:
Which chromosome is responsible for the production of MIF (Mullerian Inhibiting Factor)?
Which chromosome is responsible for the production of MIF (Mullerian Inhibiting Factor)?
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Follow the SRY testis-determining gene back to its chromosome.
Updated On: Jun 23, 2026
- Chromosome 16
- Chromosome 22
- X Chromosome
- Y chromosome
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The Correct Option is D
Solution and Explanation
Step 1: Identify MIF. Mullerian Inhibiting Factor, also called Anti-Mullerian Hormone (AMH) or Mullerian Inhibiting Substance, is a glycoprotein of the TGF-beta family secreted by the Sertoli cells of the fetal testis.
Step 2: Trace the genetic trigger. The SRY gene lies on the short arm of the Y chromosome in the sex-determining region and acts as the testis-determining factor. SRY drives testis differentiation, and the resulting Sertoli cells secrete AMH/MIF.
Step 3: Because the whole pathway that switches on MIF production is initiated by the Y-linked SRY gene, the chromosome responsible is the Y chromosome (option d).
Step 4: The distractors are incorrect: chromosomes 16 and 22 are autosomes not central to sex determination, and the X chromosome does not carry the testis-determining switch that drives MIF.
Step 2: Trace the genetic trigger. The SRY gene lies on the short arm of the Y chromosome in the sex-determining region and acts as the testis-determining factor. SRY drives testis differentiation, and the resulting Sertoli cells secrete AMH/MIF.
Step 3: Because the whole pathway that switches on MIF production is initiated by the Y-linked SRY gene, the chromosome responsible is the Y chromosome (option d).
Step 4: The distractors are incorrect: chromosomes 16 and 22 are autosomes not central to sex determination, and the X chromosome does not carry the testis-determining switch that drives MIF.
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