Question:
Which antidepressant drug can be used in nocturnal enuresis, ADHD and chronic pain?
Which antidepressant drug can be used in nocturnal enuresis, ADHD and chronic pain?
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Think of the tricyclic antidepressant classically prescribed for childhood bed-wetting.
Updated On: Jun 24, 2026
- Imipramine
- Fluvoxamine
- Bupropion
- Fluoxetine
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The Correct Option is A
Solution and Explanation
Step 1: Identify the drug class needed.
The combination of nocturnal enuresis, ADHD and chronic (neuropathic) pain points to a tricyclic antidepressant (TCA), which has well-established uses across all three indications.
Step 2: Recall imipramine's profile.
Imipramine is the classic TCA approved for childhood nocturnal enuresis (its anticholinergic action and effect on sleep architecture reduce bed-wetting). TCAs are also used off-label in ADHD and are standard agents for chronic and neuropathic pain.
Step 3: Exclude the SSRIs.
Fluvoxamine and fluoxetine are SSRIs; they are not used for enuresis or as analgesics and are not first-line for ADHD.
Step 4: Exclude bupropion.
Bupropion is used for depression and smoking cessation and has some role in ADHD, but it is not used for enuresis or chronic pain, so it does not cover all three indications.
Hence the answer is imipramine.
The combination of nocturnal enuresis, ADHD and chronic (neuropathic) pain points to a tricyclic antidepressant (TCA), which has well-established uses across all three indications.
Step 2: Recall imipramine's profile.
Imipramine is the classic TCA approved for childhood nocturnal enuresis (its anticholinergic action and effect on sleep architecture reduce bed-wetting). TCAs are also used off-label in ADHD and are standard agents for chronic and neuropathic pain.
Step 3: Exclude the SSRIs.
Fluvoxamine and fluoxetine are SSRIs; they are not used for enuresis or as analgesics and are not first-line for ADHD.
Step 4: Exclude bupropion.
Bupropion is used for depression and smoking cessation and has some role in ADHD, but it is not used for enuresis or chronic pain, so it does not cover all three indications.
Hence the answer is imipramine.
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