Question:
What was the outcome of their research?
What was the outcome of their research?
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Combine the fact about producing the genome with the fact about its sequence matching nature.
Updated On: Jul 21, 2026
- They analyzed the DNA sequence of the synthetic gene in the laboratory for the first time
- They contrasted the properties of a synthetic gene with that of a natural one
- They created a gene sequence in artificial conditions which could undergo mutation
- They produced the first synthetic genome in the laboratory which is analogous to the natural one
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The Correct Option is D
Solution and Explanation
The passage reports the overall result of the JCVI project in its opening and second paragraphs, describing both the achievement and its match to nature.
- They analyzed the DNA sequence of the synthetic gene in the laboratory for the first time: The passage confirms the sequence matched the natural one, but analyzing it is not described as the main outcome.
- They contrasted the properties of a synthetic gene with that of a natural one: The passage confirms identity between the two, not a contrast of differing properties.
- They created a gene sequence in artificial conditions which could undergo mutation: Mutation is never mentioned as part of this research in the passage.
- They produced the first synthetic genome in the laboratory which is analogous to the natural one: This matches both the statement that they produced the first synthetic genome and the confirmation that its DNA sequence was identical to the natural one.
The correct option is the fourth one, since it combines both key facts about the outcome stated in the passage.
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The DNA sequence of the synthetic one was confirmed to be identical to the natural one. While the DNA pieces were synthesized chemically, the stitching together was done using the biochemical machinery of a host cell. About 100 pieces of the genome, each 5000-7000 units long in DNA sequence, were first joined to produce 25 sub-assemblies, each about 24000 base pairs long. These were then introduced into the bacterium E. coli to produce sufficient DNA for the next steps. Next, they repeated the procedure to generate large fragments comprising l/4th of the whole genome of M.genitalium.
Now, they used the clever trick of exploiting the process called homologous recombination. This is a basic essential process in every cell, which physically rearranges the two strands of DN The JCVI researchers inserted the synthesized DNA fragments into yeast and utilized its homologous recombination ability to generate the whole 580,000 long genome of M.genitalium in one step.
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This surely raises ethical questions, a matter that JCVI is keenly aware of and is already engaged in with ethicists. Even their present work on M.genitalium was done with prior approval of ethical experts. But then, today it is M.genitalium, tomorrow it could be a more advanced, multi-cellular organism, and that could flummox even the ethicist. Assisted reproduction, which is the other side of the coin and truly a recently initiated technology, has become ethically and morally acceptable. Cloning of Dolly, the sheep, has not raised any outrage, but cloning a human certainly does. - The technological trajectory traversed in communications and transport from pigeon mail and pony expressto e-mail and videoconferencing is almost as great as the intellectual space between Noah's Ark and the biotechnological revolution in the preservation and improvement of the species. Dreams are multi-hued today and soar beyond the hitherto accepted bounds of human endeavor.
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This anxiety does not dissipate, and in fact, it can increase to the level where it begins to change your behavior. That’s when it’s characterized as an anxiety disorder. Anxiety can keep you safe, helping you recognize danger, and cope with it, says Mooney. But if you begin to see danger lurking around every corner, or worry over and over again about the same events, then you might be dealing with something more substantial, like an anxiety disorder.
People with anxiety disorders often begin to avoid activities or circumstances that make them anxious, said John Forsyth, associate professor of Psychology at the State University of New York at Albany and director of the Anxiety Disorders Research Programme at the university. People may stop driving, or stop going to parties. They may stop travelling or even avoid leaving the house. It’s this curtailing of activities that causes the suffering, Forsyth said, making you feel that ‘life is shrinking around you.’
Anxiety disorders come in a variety of forms and manifest themselves in different ways. Generalized anxiety disorder is characterized by ongoing worry about everyday tasks, even when there is no clear reason to worry. People with social anxiety disorder experience intense worry over social interactions, and often feel judged by people or worry that they will embarrass themselves. Post-traumatic stress disorder, which is characterized by people re-living a frightening event over and over again, is also considered an anxiety disorder. Obsessive-compulsive disorder is when people take on obsessive rituals that help them maintain the illusion of control. Often repetitive in nature, obsessive compulsive rituals can include cleaning, checking and rechecking something, counting or endlessly reviewing conversations in their mind. Treatment is available for anxiety disorders. People can use a variety of approaches, including therapy, medication and exercise. - I am the family face; flesh perishes. I live on, projecting trait and trace through time to times anon, and leaping from place to place over oblivion.
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The DNA sequence of the synthetic one was confirmed to be identical to the natural one. While the DNA pieces were synthesized chemically, the stitching together was done using the biochemical machinery of a host cell. About 100 pieces of the genome, each 5000-7000 units long in DNA sequence, were first joined to produce 25 sub-assemblies, each about 24000 base pairs long. These were then introduced into the bacterium E. coli to produce sufficient DNA for the next steps. Next, they repeated the procedure to generate large fragments comprising l/4th of the whole genome of M.genitalium.
Now, they used the clever trick of exploiting the process called homologous recombination. This is a basic essential process in every cell, which physically rearranges the two strands of DN The JCVI researchers inserted the synthesized DNA fragments into yeast and utilized its homologous recombination ability to generate the whole 580,000 long genome of M.genitalium in one step.
This is clearly a landmark work that leads into the brave new world of synthesizing life itself in the laboratory. It was hardly 200 years ago when Friedrich Wohler synthesized urea, an organic molecule, in the chemical laboratory, thus throwing out the notion of ‘vital forces’ involved in the components of living organisms. What is the next step, making life itself in the lab, bypassing nature? With single cell organisms like M.genitalium, it might not be far away. It is now possible in the lab to do so, by inserting the genome into a ‘host’ cell and asking the latter to make the bacterium of your choice. If only we find a way to insert the bacterial genome into this proto-cell, and somehow trigger it to make the bacterium itself! We would have chemically created life in the la This is not a pipedream; JCVI scientists are already on the job, and my bet is they will do it within a few years.
This surely raises ethical questions, a matter that JCVI is keenly aware of and is already engaged in with ethicists. Even their present work on M.genitalium was done with prior approval of ethical experts. But then, today it is M.genitalium, tomorrow it could be a more advanced, multi-cellular organism, and that could flummox even the ethicist. Assisted reproduction, which is the other side of the coin and truly a recently initiated technology, has become ethically and morally acceptable. Cloning of Dolly, the sheep, has not raised any outrage, but cloning a human certainly does. - The technological trajectory traversed in communications and transport from pigeon mail and pony expressto e-mail and videoconferencing is almost as great as the intellectual space between Noah's Ark and the biotechnological revolution in the preservation and improvement of the species. Dreams are multi-hued today and soar beyond the hitherto accepted bounds of human endeavor.
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An actor, essayist, screenwriter, poet, director and dramatist, Pinter was also publicly outspoken in his views on repression and censorship, at home and abroad. He used his Nobel acceptance speech to denounce Amer- ican foreign policy, saying that the United States had not only lied to justify waging war against Iraq, but that it had also 'supported and in many cases engendered every right-wing military dictatorship' in the last 50 years. His political views were implicit in much of his work. Though his plays deal with the slipperiness of memory and human character, they are also almost always about the struggle for power.
In Pinter's work 'words are weapons that the characters use to discomfort or destroy each other' said Peter Hall, who has staged more of Pinter's plays than any other director. But while Pinter's linguistic agility turned simple, sometimes obscene, words into dark, glittering and often mordantly funny poetry, it is what comes between the words that he is most famous for. And the stage direction 'pause' would haunt him throughout his career.
Intended as an instructive note to actors, the Pinter pause was a space for emphasis and breathing room. But it could also be as threatening as a raised fist. Pinter said that writing the word 'pause' into his first play was 'a fatal error'. It is certainly the aspect of his writing that has been most parodied. But no other playwright has consistently used pauses with such rhythmic assurance and to such fine-tuned manipulative effect. Early in his career, Pinter said his work was about 'the weasel under the cocktail cabinet'. Though he later regretted the image, it holds up as a metaphor for the undertow of danger that pervades his work.
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