Question:
What is the most common location of gastrinoma in MEN-1 syndrome?
What is the most common location of gastrinoma in MEN-1 syndrome?
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In MEN-1 the gastrinomas are small, multiple and sit in the first part of the small bowel, not the pancreas.
Updated On: Jun 23, 2026
- Duodenum
- Jejunum
- Pancreas
- Ileum
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The Correct Option is A
Solution and Explanation
Answer: Duodenum.
Context: Pancreatic and duodenal neuroendocrine tumours occur in roughly half of MEN-1 patients. Among the functional ones, gastrinoma is the most common, and in MEN-1 these gastrinomas are typically small, multiple and located in the duodenum rather than the pancreas.
Why option A: The most frequent site of a MEN-1 associated gastrinoma is the duodenum (the so-called gastrinoma triangle, especially the first and second parts), followed by insulinoma, which is the next most common functional tumour and is pancreatic.
Why the others are wrong: Sporadic gastrinomas can be pancreatic, but in MEN-1 the duodenum is the dominant site, so pancreas (C) is not the best answer here. Jejunum (B) and ileum (D) are not typical gastrinoma sites.
Ref: Bailey and Love, Short Practice of Surgery, 27e, Pg 856.
Context: Pancreatic and duodenal neuroendocrine tumours occur in roughly half of MEN-1 patients. Among the functional ones, gastrinoma is the most common, and in MEN-1 these gastrinomas are typically small, multiple and located in the duodenum rather than the pancreas.
Why option A: The most frequent site of a MEN-1 associated gastrinoma is the duodenum (the so-called gastrinoma triangle, especially the first and second parts), followed by insulinoma, which is the next most common functional tumour and is pancreatic.
Why the others are wrong: Sporadic gastrinomas can be pancreatic, but in MEN-1 the duodenum is the dominant site, so pancreas (C) is not the best answer here. Jejunum (B) and ileum (D) are not typical gastrinoma sites.
Ref: Bailey and Love, Short Practice of Surgery, 27e, Pg 856.
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