Question

Von Willebrand factor is synthesized by all except?

• A. Endothelial cells
• B. Megakaryocytes
• C. Hepatocytes
• D. None

Hint:

Endothelium and megakaryocytes make it; one classic liver-made exception remains.

Answer 1

The Correct Option is C

Step 1: This is a negative question - find the cell that does NOT make von Willebrand factor (vWF).

Step 2: vWF is produced by two cell types: vascular endothelial cells (the main source, stored in Weibel-Palade bodies) and megakaryocytes (stored in platelet alpha-granules). Both options a and b are therefore true sources.

Step 3: Hepatocytes synthesize most clotting factors, but vWF is the exception - it is not made by liver cells. Note that the coagulant part of factor VIII (factor VIIIc) is made in the liver, but vWF (the carrier that protects factor VIII) is not.

Step 4: So the cell that does not synthesize vWF, and hence the correct answer, is the hepatocyte.