Question:
Vasopressin acts through which channels in the collecting duct?
Vasopressin acts through which channels in the collecting duct?
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ADH inserts a specific aquaporin into the apical membrane of principal cells.
Updated On: Jun 23, 2026
- Aquaporin 1
- Aquaporin 2
- GLUT-1
- GLUT-4
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The Correct Option is B
Solution and Explanation
Step 1: Vasopressin, also called antidiuretic hormone (ADH) or arginine vasopressin (AVP), regulates water reabsorption in the renal collecting duct.
Step 2: The principal cells of the collecting duct carry a regulated system of water channels. ADH controls how permeable these cells are to water.
Step 3: ADH acts by promoting the insertion of pre-formed aquaporin-2 (AQP2) water channels into the apical (luminal) membrane of the principal cells, increasing water reabsorption. So option (b) is correct.
Step 4: Aquaporin 1 is found mainly in the proximal tubule and descending limb (not ADH regulated), while GLUT-1 and GLUT-4 are glucose transporters and have no role in collecting duct water handling.
Step 2: The principal cells of the collecting duct carry a regulated system of water channels. ADH controls how permeable these cells are to water.
Step 3: ADH acts by promoting the insertion of pre-formed aquaporin-2 (AQP2) water channels into the apical (luminal) membrane of the principal cells, increasing water reabsorption. So option (b) is correct.
Step 4: Aquaporin 1 is found mainly in the proximal tubule and descending limb (not ADH regulated), while GLUT-1 and GLUT-4 are glucose transporters and have no role in collecting duct water handling.
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